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Marihuana osłabia odporność

Marihuana osłabia odporność

Kannabinoidy, związki chemiczne występujące w konopi indyjskiej, osłabiają funkcjonowanie układu odpornościowego – informują naukowcy na łamach „European Journal of Immunology”. Najnowsze badania stanowią wyjaśnienie, dlaczego osoby regularnie palące marihuanę są bardziej narażone na niektóre rodzaje nowotworów.

Międzynarodowy zespół immunologów skoncentrował się podczas swoich badań na kannabinoidach, w tym THC (tetrahydrokannabinol), które obecnie są już wykorzystywane do celów medycznych, m.in. łagodzenia bólu.

Marihuana jest jednym z najczęściej stosowanych narkotyków na świecie i wiemy już, że hamuje ona funkcje immunologiczne, przez co osoby palące marihuanę są bardziej podatne na infekcje i niektóre rodzaje raka. Uważamy, że kluczową rolę pełni w tym procesie specyficzny typ komórek odpornościowych, który niedawno został zidentyfikowany przez naukowców. Są to mieloidalne komórki supresorowe (MDSC) – wyjaśnia nadzorujący pracę badaczy dr Prakash Nagarkatti z Uniwersytetu Karoliny Południowej.

Choć w większości przypadków komórki odpornościowe walczą z infekcjami i komórkami nowotworowymi, chroniąc gospodarza, MDSC aktywnie blokują pracę układu odpornościowego. Liczba tych komórek zwiększa się u pacjentów z nowotworami. Mogą one utrudniać leczenie i przyczyniać się do dalszego rozwoju choroby.

Jak się okazuje, zawarte w marihuanie kannabinoidy mogą aktywować ogromne ilości komórek MDSC poprzez oddziaływanie na receptory kannabinoidowe, a tym samym upośledzać działanie układu immunologicznego.

Pismo informuje także o innych badaniach, przeprowadzonych przez dra Christiana Vosshenricha z Instytutu Pasteura w Paryżu, z których wynika, że wraz z rozwojem raka komórki nowotworowe produkują interleukinę 1 beta (IL-1ß) również aktywującą MDSC.

Z jednej strony, ze względu na swoją immunosupresyjną naturę, kannabinoidy mogą zwiększać ryzyko nowotworów i infekcji, z drugiej jednak dalsze badania nad tymi związkami mogą otworzyć możliwości leczenia szerokiej gamy dolegliwości, gdzie blokowanie odpowiedzi immunologicznej może być w rzeczywistości korzystne dla pacjenta – konkluduje dr Nagarkatti.

via: PAP



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